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Deep, targeted following-generation sequencing has discovered that subclonal mutations (i.e., those present in only a fraction of tumor cells) might be detected for all driver genes and therefore are related to swift disease progression and lousy consequence.11–thirteen This is particularly relevant for TP53 mutations presented The truth that, as stated under, CLL therapy relies around the presence or absence of such mutations. The existing consensus is that, besides clonal mutations, subclonal mutations by using a variant allelic frequency ranging from 5 to 10% (and for that reason below the edge of detection by traditional molecular methods) is also documented, whereas those which has a variant allelic frequency reduce than 5% should not, but there is A great deal controversy all around these issues which suggestion may well adjust in the future.
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東南海・南海地震における浄水場 のリスクに関する一考察（その２） 中井 c加振振動数を変化させた実験 地震動の振動数の変化が，ろ過水濁度上昇に与え る影響を明らかにするため，入力加速度 150gal，継 続時間
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